Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery

Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery.

Pullulan-based nanoparticles as carriers for transmucosal protein delivery.

Polymeric nanoparticles have revealed very effective in transmucosal delivery of proteins. Polysaccharides are among the most used materials for the production of these carriers, owing to their structural flexibility and propensity to evidence biocompatibility and biodegradability. In parallel, there is a preference for the use of mild methods for their production, in order to prevent protein d...

Pullulan Acetate Nanoparticles Based Delivery System for Hydrophobic Drug

Silymarin is having antioxidant and membrane stabilizing property and acts as a defensive material in different toxic forms of liver diseases like liver cirrhosis, alcoholic liver disease. Pullulan is a good water soluble neutral linear polysaccharide consisting of α-1,6 linked maltotriose residues. It is broadly used as a food additive and is considered to be safe for human use. In the present...

Dossier: Drug delivery and drug efficacy Principles of transmucosal delivery of therapeutic agents

Recent advances in medicine have led to new treatment options for patients and physicians as a more developed understanding of the molecular basis of disease states is translated into new therapeutic agents. Many of these new agents are compounds that are not able to reach the bloodstream when administered by the oral route preventing the ability to enjoy the benefits this delivery route provid...

Chitosan-based Nanoparticles in Mucosal Vaccine Delivery

Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...